|
T9745 |
Elevenostat
|
|
HDAC
|
|
Elevenostat is an HDAC11-selective inhibitor with an IC50 value of 0.235 µM. |
|
T6800 |
CCF642
|
AC1LYELL |
Others
|
|
CCF642 (AC1LYELL) is a novel PDI-inhibiting compound with antimyeloma activity. |
|
T22277 |
BMS-P5
|
|
PAD
|
|
BMS-P5 is a specific and orally active Peptidylarginine Deiminase 4 (PAD4) inhibitor. |
|
T9370 |
DCBP-1
|
|
Epigenetic Reader Domain
,
Ligand for E3 Ligase
|
|
dCBP-1 is a chemical degrader of p300/CBP. dCBP-1 hijacks the E3 ubiquitin ligase CRBN for selective degradation of p300/CBP. Degradation of p300/CBP by dCBP-1 leads to effective multiple myeloma cell killing. |
|
T5484 |
GSK467
|
|
Histone Demethylase
,
Histone Methyltransferase
|
|
GSK467 is a potent and selective inhibitor of KDM5 (JARID1)(Ki : 10 nM). |
|
T8719 |
SC99
|
|
Apoptosis
,
JAK
,
STAT
|
|
SC99 is a selective inhibitor of JAK2-STAT3 activation. SC99 downregulates the expression of STAT3-modulated genes.SC99 inhibits platelet activation, aggregation and displays potent anti-myeloma, anti-thrombotic activiti... |
|
T3971 |
CASIN
|
Pirl1-related Compound 2 |
CDK
,
STAT
,
Ras
|
|
CASIN (Pirl1-related Compound 2) is a specific inhibitor of GTPase Cdc42 (IC50: 2 uM). |
|
T6796 |
CB-5083
|
CB5083,CB 5083 |
p97
|
|
CB-5083 is a potent, selective, and orally bioavailable p97 AAA ATPase inhibitor ( IC50=11 nM). |
|
T12871 |
Talmapimod
|
SCIO-469 |
p38 MAPK
|
|
Talmapimod (SCIO-469) is an selective, orally active, and ATP-competitive p38α inhibitor with IC50 of 9 nM and 90 nM for p38α and p38β, respectively. Talmapimod exhibits at least 2000-fold selectivity over a panel of 20 ... |
|
T41290 |
MST-312
|
Telomerase Inhibitor IX |
Telomerase
|
|
MST-312 (Telomerase Inhibitor IX) is a derivative of green tea epigallocatechin gallate (EGCG). MST-312 is a telomerase inhibitor. MST-312 has research value in cancer, such as multiple myeloma (MM). |
|
T9573 |
GSK3685032
|
|
DNA Methyltransferase
|
|
GSK3685032 is a non-covalent and selective DNMT1 inhibitor(IC50 = 36 nM). The inhibitory effect is time-independent and reversible. GSK3685032 induces loss of DNA methylation and transcriptional activation and inhibits c... |
|
T22277L |
BMS-P5 free base
|
|
PAD
|
|
BMS-P5 free base is a specific and orally active peptidylarginine deiminase 4 (PAD4) inhibitor. BMS-P5 Blocks Formation of Neutrophil Extracellular Traps and Delays Progression of Multiple Myeloma. Administration of BMS-... |
|
T8342 |
BRD9876
|
|
Others
,
Kinesin
,
Microtubule Associated
|
|
BRD9876 is a selective inhibitor of MM1S growth. |
|
T22922 |
Lenalidomide hemihydrate
|
|
TNF
,
Ligand for E3 Ligase
,
Molecular Glues
|
|
Lenalidomide hemihydrate is a TNF-α secretion inhibitor (IC50 = 13 nM). Lenalidomide hemihydrate could bound endogenous CRBN and recombinant CRBN-DNA damage binding protein-1 (DDB1) complexes. |
|
T7779 |
Nelfinavir
|
AG1341 |
HIV Protease
|
|
Nelfinavir (AG1341) is an antiretroviral drug used in the treatment of the human immunodeficiency virus (HIV) (Ki=2 nM). Nelfinavir is a broad-spectrum, anticancer agent. |
|
T3661 |
Citarinostat
|
ACY241,HDAC-IN-2 |
HDAC
|
|
ACY-241, also known as Citarinostat (ACY241), is a potent, selective and orally available histone deacetylase (HDAC) inhibitor, with potential antineoplastic activity. Upon oral administration, ACY-241 inhibits the activ... |
|
T1642 |
Lenalidomide
|
CC-5013 |
Apoptosis
,
TNF
,
Ligand for E3 Ligase
,
Molecular Glues
|
|
Lenalidomide (CC-5013) is a potent inhibitor of TNF-α that, at 10 μM, alters gene expression and cell viability in a range of cancer cell lines. |
|
T1979 |
AVN-944
|
VX-944 |
Dehydrogenase
|
|
AVN-944 (VX-944)(VX-944) is a selective, noncompetitive inhibitor of human IMPDH with Ki of 6-10 nM for IMPDH1/IMPDH2. |
|
T7791 |
Iberdomide
|
CC-220 |
Apoptosis
,
Ligand for E3 Ligase
|
|
Iberdomide (CC-220) is a modulator of cereblon( IC50 value of 60 nM in a competitive TR-FRET assay). |
|
T4134 |
OTS514 hydrochloride
|
OTS-514 hydrochloride,OTS514 hydrochloride(1338540-63-8(free base)) |
Apoptosis
,
TOPK
|
|
OTS514 hydrochloride is a highly effective TOPK(T-LAK cell-originated protein kinase) inhibitor (IC50: 2.6 nM). |
|
T6079 |
NVP-ADW742
|
ADW742,ADW,GSK 552602A |
Apoptosis
,
IGF-1R
|
|
NVP-ADW742 (ADW) is an IGF-1R inhibitor with IC50 of 0.17 μM, >16-fold more potent against IGF-1R than InsR; little activity to HER2, PDGFR, VEGFR-2, Bcr-Abl and c-Kit. |
|
T6001 |
Nelfinavir Mesylate
|
Viracept,Nelfin,AG1343,AG 1343 Mesylate |
HIV Protease
|
|
Nelfinavir Mesylate (Viracept) is an effective HIV protease inhibitor (Ki: 2 nM). |
|
T1776 |
Plerixafor
|
JM3100,AMD 3100,AMD-3329 |
Virus Protease
,
HIV Protease
,
CXCR
|
|
Plerixafor (AMD-3329), a chemokine receptor antagonist, blocks the binding of stromal cell-derived factor (SDF-1alpha) to the cellular receptor CXCR4. |
|
T2241 |
Alisertib
|
MLN 8237 |
Apoptosis
,
Aurora Kinase
,
Autophagy
|
|
Alisertib (MLN 8237) is a specific Aurora A inhibitor (IC50: 1.2 nM). The selectivity of Alisertib(MLN 8237) is >200-fold higher for Aurora A than Aurora B. |
|
T21503 |
(E/Z)-Zotiraciclib
|
(E/Z)-TG02,(E/Z)-SB1317 |
FLT
,
JAK
,
CDK
|
|
(E/Z)-Zotiraciclib ((E/Z)-TG02) inhibits CDK2, JAK2, and FLT3 effectively with IC50s of 13, 73, and 56 nM, respectively. |
|
TP1540 |
Jagged-1 （188-204）
|
Jagged-1 188-204 |
Gamma-secretase
|
|
Jagged-1 （188-204）is a fragment of the JAG-1 protein. JAG-1 is Notch ligand, a peptide that is the most conspicuously expressed ligand in skin. JAG-1 induces epidermal maturation. Exposing submerged keratinocytes monolay... |
|
T4134L |
OTS514
|
OTS514 HCl,OTS514 Hydrochloride,OTS-514,OTS 514 |
Apoptosis
,
TOPK
|
|
OTS514 (OTS514 Hydrochloride) is a potent TOPK inhibitor. OTS514 exhibits a growth-suppressive effect on small cell lung cancer. OTS514 effectively suppressed the growth of SCLC cell lines (IC50: 0.4 ~ 42.6 nM). Treatmen... |
|
T11141 |
E64FC26
|
|
Others
|
|
E64FC26 is a potent protein disulfide isomerase (PDI) family pan-inhibitor with antitumor activity, inhibits PDIA1, PDIA3, PDIA4, TXNDC5 and PDIA6, and can be used in the study of multiple myeloma and pancreatic cancer. |
|
T14918 |
CDK9-IN-2
|
|
Others
,
CDK
|
|
|
|
T13905 |
Stilbamidine
|
Ba 2652,Stilbamidin |
Antifungal
|
|
Stilbamidine (Ba 2652) has antifungal and anticancer activity and can be used to study multiple myeloma and bladder migratory cell carcinoma. |
|
T76882 |
Talquetamab
|
JNJ-64407564,JNJ-7564 |
Dopamine Receptor
|
|
Talquetamab (JNJ-64407564) is a T-cell retargeting GPRC5D bispecific antibody for multiple myeloma with antitumor activity that induces T-cell-mediated killing of GPRC5-expressing MM cells through T-cell recruitment and ... |
|
T39989L |
JQKD82 trihydrochloride
|
|
Histone Demethylase
|
|
JQKD82 trihydrochloride, a cell-permeable and selective inhibitor of KDM5, enhances H3K4me3 levels and is utilized in multiple myeloma research. |
|
T27582 |
ICRT-5
|
iCRT 5,iCRT5 |
Apoptosis
,
Wnt/beta-catenin
|
|
iCRT-5 is a potent inhibitor of the Wnt pathway. iCRT-5 has antiproliferative activity, blocking Wnt/β-catenin expression and inducing apoptosis. iCRT-5 can be used in the study of multiple myeloma. |
|
TQ0101 |
MKC3946
|
|
IRE1
|
|
MKC3946 is an effective and soluble IRE1α inhibitor which triggered modest growth inhibition in multiple myeloma cell lines. |
|
T9006 |
LEM-14
|
|
Others
|
|
LEM-14 is a potent NSD2-specific inhibitor (IC50:132 μM).LEM-14 may be used in the study of multiple myeloma. |
|
T23911 |
CPS-11
|
CPS11,CPS 11,N-(Hydroxymethyl)thalidomide |
Dehydrogenase
,
NF-κB
,
Reactive Oxygen Species
|
|
CPS-11 (N-(Hydroxymethyl)thalidomide) is a Thalidomide analogue that has significant antitumor activity and exhibits a wider range of activity and highly potent effects on the MM (multiple myeloma) cell line. |
|
T61556 |
GRK6-IN-2
|
|
GRK
|
|
GRK6-IN-2 is a potent G protein-coupled receptor kinase 6 (GRK6) inhibitor with potential antitumor activity.GRK6-IN-2 has been studied in multiple myeloma. |
|
T76927 |
Bersanlimab
|
BI-505 |
Integrin
|
|
Bersanlimab (BI-505) is a fully human monoclonal antibody targeting Intercellular Adhesion Molecule-1 (ICAM-1).Bersanlimab has anticancer properties and can be used to study relapsed/refractory multiple myeloma. |
|
T77006 |
Felzartamab
|
TJ-202,MOR-03087,MOR-202 |
CD38
|
|
Felzartamab(MOR-202) is a human-targeted monoclonal antibody to CD38 for the study of multiple myeloma and advanced antibody-mediated rejection of allogeneic kidney transplants. |
|
T9918 |
Daratumumab
|
|
Others
|
|
Daratumumab is a human monoclonal antibody that targets CD38 a cell surface protein that is overexpressed on multiple myeloma MM) cells. |
|
TP1806L |
BCMA72-80 acetate(2293841-58-2 free base)
|
|
Others
|
|
BCMA72-80 acetate is a HLA-A2 specific B cell maturation antigen (BCMA) peptide. It is used to study multiple myeloma and tumors, which expresses B cell maturation antigen. |
|
T1795 |
Carfilzomib
|
PR-171 |
Apoptosis
,
Proteasome
,
Autophagy
|
|
Carfilzomib (PR-171) is a proteasome inhibitor that irreversibly binds to the chymotrypsin of the 20S proteasome. Carfilzomib has antitumor activity and may be used to treat multiple myeloma. |
|
T2709 |
TAK-901
|
TAK901 |
JAK
,
CDK
,
Src
,
Aurora Kinase
|
|
TAK-901 has been used in trials studying the treatment of Lymphoma, Myelofibrosis, Multiple Myeloma, Myeloid Metaplasia, and Advanced Solid Tumors, among others. |
|
T6106 |
Selinexor (KPT-330)
|
Selinexor,KPT-330 |
CRM1
|
|
Selinexor (KPT-330) is a small molecule inhibitor of CRM1 with selective and oral activity. Selinexor blocks the cell cycle, induces apoptosis, and has antitumor activity for the treatment of multiple myeloma. |
|
T77685 |
6-Bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile
|
|
PDK
|
|
6-Bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile is a PDK1 inhibitor with anticancer and antiproliferative activity that can be used to study angiosarcoma, adenocarcinoma, multiple myeloma, psoriasis, prostate can... |
|
T35386 |
Elotuzumab
|
Elotuzumab (anti-SLAMF7),BMS 901608,PDL 063,HuLuc 63 |
Others
|
|
Elotuzumab(HuLuc 63) is a monoclonal antibody that targets the SLAMF7 receptor.Elotuzumab is a compound that directly activates NK cells and induces antibody-dependent cytotoxicity, and can be used in combination with le... |
|
T9969 |
EZM0414
|
|
Histone Methyltransferase
|
|
EZM0414 is a potent, selective, orally bioavailable inhibitor of SETD2 with IC50 of 18 nM in SETD2 biochemical assay and IC50 of 34 nM in a cellular assay. EZM0414 can be used for the research of relapsed or refractory m... |
|
T12660L |
BAY1238097
|
|
Epigenetic Reader Domain
|
|
|
|
T72979 |
LEM-14-1189
|
|
Histone Methyltransferase
|
|
Lem-14-1189, a LEM-14 derivative, is a potent NSD inhibitor of the nuclear receptor binding SET domain, and has inhibitory effects on NSD1, NSD2, and NSD3, with IC50 of 418 μM, 111 μM, and 60 μM, respectively. LEM-14-118... |
|
T76794 |
Ulocuplumab
|
BMS 936564,MDX 1338 |
Apoptosis
,
CXCR
|
|
Ulocuplumab (BMS-936564) is a fully human anti-CXCR4 IgG4 antibody.Ulocplumab exhibits antitumor activity in acute myeloid leukemia (AML), non-Hodgkin's lymphoma (NHL), and multiple myeloma transplantation models.Ulocplu... |
